Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of coronavirus disease 2019 (COVID-19). Choosing to participate in a study is an important personal decision. Information provided by (Responsible Party): Prof Simon Karanja, Jomo Kenyatta University of Agriculture and Technology. PMC 2023 Apr 17:103340. doi: 10.1016/j.autrev.2023.103340. and transmitted securely. Bookshelf Adverse events, including severe allergic reactions, after COVID-19 vaccination are rare but can happen.For this reason, everyone who receives a COVID-19 vaccine is monitored by their vaccination provider for at least 15 minutes. https://bioiron.org/news/iron-stories/normal-iron-hemoglobin-levels-covid19-vaccination.aspx. This work was supported by National Institutes of Health, National Heart, Lung, and Blood Institute grants R01 HL 133113 (R.A.B.) Aplastic anemia (AA), a bone marrow failure syndrome, appears to be immune-mediated [4,5]. She had a favorable clinical Anemia can affect your weight, whether due to its impact on your appetite and activity levels or its underlying cause. 2023 Jan 14;44(1):19-25. doi: 10.3760/cma.j.issn.0253-2727.2023.01.004. Vaccination and autoimmune disease: what is the evidence? Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan. denotes no information is available; AST, aspartate amino transferase; LDH, lactate dehydrogenase; N/A, not applicable; RBC red blood cell. Skip Navigation COVID-19 Updates Five with Evans syndrome, all preexisting. 1,2 Billions of doses of vaccine have been Unless his levels quickly return to normal, he needs a complete panel and physician consult to know what is going on. His iron, ferritin and red blood cell count is extremely low. Our study objective is to assess whether iron deficiency anaemia in young women impairs their immune response to the COVID-19 vaccine, and whether iron treatment improves their response. In spite of the administration of cyclosporine and eltrombopag, his pancytopenia progressed. On the evening after his first dose of the Pfizer-BioNTech vaccine, he experienced fever, headache, myalgia, and severe fatigue, which lasted 6 days. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. Published April 20, 2023 at 8:20 AM EDT. All Rights Reserved. -, Gaignard ME, Lieberherr S, Schoenenberger A, Benz R. Autoimmune hematologic disorders in two patients after mRNA COVID-19 vaccine. Keywords: We report a case of severe AA that arose after the administration of a COVID-19 vaccine (the Pfizer-BioNTech mRNA vaccine), which was treated with allogeneic hematopoietic stem cell transplantation (HSCT). 2021 Dec;74:103705. doi: 10.1016/j.ebiom.2021.103705. Hematological abnormalities in COVID-19: A narrative review. (2021). We avoid using tertiary references. Anemia of inflammation or chronic disease. Chimerism analysis performed on day 29 after the HSCT revealed complete chimerism in the peripheral blood. Reported cases of newly diagnosed aplastic anemia after vaccinations. With COVID-19, its believed to occur due to an autoimmune effect or direct injury to RBCs, according to 2022 research. Eur J Haematol. Intern Med. Anemia can also happen with COVID-19. Eighteen days after vaccination, ecchymosis appeared on the injection site of insulin. Epub 2021 Nov 30. Elsevier Public Health Emergency Collection, https://doi.org/10.1016/j.jaut.2021.102782, https://doi:10.1046/j.1365-2141.2000.02171.x, https://doi:10.1046/j.1365-2141.2001.03006-2.x, https://doi:10.1016/S1473-3099(20)30130-4, https://doi:10.1016/S0140-6736(03)14802-7, https://doi:10.1182/bloodadvances.2019000853. A 73-year-old male patient with a medical history of hypertension, diabetes mellitus on insulin therapy, hyperlipidemia, coronary artery bypass grafting, and iron deficiency anemia received the first dose of Pfizer-BioNTech COVID-19 vaccination on 21 st, 2021. Aplastic anemia can be treated with medications, blood transfusions, and even bone marrow stem cell transplants. Al-kuraishy HM, et al. Yes. 2022 Jul 20;12(4):200-223. doi: 10.5662/wjm.v12.i4.200. -, Nagashima T, Minota S. Autoimmune hemolytic anemia induced by adalimumab. Our website services, content, and products are for informational purposes only. S.C. has served on advisory boards for Alexion and Sanofi-Genzyme, and her institution has received research funding on her behalf from Takeda. No relevant conflicts of interest to declare. Sue. Learn more. Accessibility We report a case of severe AA that arose after the administration of a COVID-19 vaccine (the Pfizer-BioNTech mRNA vaccine), which was treated with allogeneic hematopoietic stem cell transplantation (HSCT). How does COVID-19 affect you if you have anemia? Shotaro Tabata: Data curation, Investigation, Writing original draft; Hiroki Hosoi: Conceptualization, Data curation, Investigation, Writing original draft and Review & Editing; Shogo Murata: Investigation, Writing review & editing; Satomi Takeda: Data curation, Writing review & editing; Toshiki Mushino: Writing review & editing; Takashi Sonoki: Writing review & editing, Supervision. Research has found that COVID-19 with anemia is associated with more severe symptoms in people hospitalized for COVID-19. Panel B: H.E. You have reached the maximum number of saved studies (100). FACT: The Pfizer and Moderna COVID-19 vaccines can have side effects, but the vast majority are very short term not serious or dangerous. eCollection 2023 Feb. Jacobs JW, Booth GS, Guarente J, Schlafer D, Zheng L, Adkins BD. Another 2021 study of 137 people with COVID-19 found that participants with anemia were 8.2 times more likely than participants without anemia to have severe pneumonia. Kayukawa S, Nanya K, Morita M, Ina K, Ota Y, Hasegawa S. Microbiol Spectr. Symptoms may include: Abnormal paleness or lack of color of the skin Irritability Lack of energy or tiring easily (fatigue) Increased heart rate (tachycardia) Sore or swollen tongue Enlarged spleen Blood 2021; 137 (26): 36703673. Federal government websites often end in .gov or .mil. He was admitted to our hospital due to progressive pancytopenia (Supplementary Table 1). However, in general, AA is not recognized as a vaccine-related adverse event [12]. We don't think this is going to reveal anything. COVID-19 and Immune-Mediated RBC Destruction. sharing sensitive information, make sure youre on a federal Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. Seroresponse to SARS-CoV-2 Vaccines among Maintenance Dialysis Patients over 6 Months. -. Epub 2021 Nov 10. He received the Pfizer vaccine and his blood which has never been low in iron was low in iron. Aplastic anemia following varicella vaccine. Arepally G.M., Ortel T.L. The FDA has granted breakthrough therapy designation to an investigational respiratory syncytial virus vaccine candidate, mRNA-1345 from Moderna, for individuals 60 years and older. He had an 1 g/dL hemoglobin decrease on laboratory tests 3 days following his first vaccination. There is scanty material about relapse of autoimmune hematological diseases after vaccination for COVID-19 (Blood Adv 2021;13:2794-2798). The gray boxes indicate the titers of antibodies against the SARS-CoV-2 spike protein (log scale). eCollection 2022 Jul 20. Aplastic anemia occurs when your bone marrow doesn't make enough red and white blood cells, and platelets. 2021;5(8):e618. Learn more about the connection between tinnitus and COVID-19, and what you can, You may have heard claims that green tea prevents or cures COVID-19. The development of various autoimmune diseases has been reported after COVID-19 infections or vaccinations. He began feeling more tired over the next two months. The state of vaccine safety science: systematic reviews of the evidence. Low levels of any of these may mean they have aplastic anemia. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04915820, We're building a modernized ClinicalTrials.gov! Histological findings of the bone marrow biopsy specimen at diagnosis. Its unclear if and how anemia affects people with milder COVID-19 symptoms who dont require hospitalization. He experienced fatigue and darkening of his urine following his first dose of the Moderna vaccine. World J Methodol. The Coronavirus Disease 2019 (COVID-19) pandemic has affected the entire globe. Patients 5 and 6 received both doses of the Pfizer-BioNTech BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine without clinical or laboratory signs of hemolysis. Between December 2020 and June 2021 there were identified 53 patients with autoimmune hematological disease that completed SARS-Cov2 vaccination. As seen in patients 3 and 6, a proximal complement inhibitor, such as danicopan, may prevent breakthrough hemolysis precipitated by the vaccine; however, it is equally possible that the stronger immune response after the second vaccine dose was primarily responsible for the breakthrough hemolysis in patient 3. Yes. Indications for surgical splenectomy include trauma, intractable anemia, or symptomatic splenomegaly. Women in both groups will receive the 1st dose of the COVID-19 vaccine. The measurement of anti-SARS-CoV-2 spike protein antibody titers was performed by SRL, Inc. (Tokyo, Japan) using the Elecsys anti-SARS-CoV-2 S immunoassay (Roche, Basel, Switzerland). Disclaimer. 2022;63(9):1067-1077. doi: 10.11406/rinketsu.63.1067. The online version of this article contains a data supplement. The https:// ensures that you are connecting to the Nurse getting ready to administer a vaccine. Epub 2022 Nov 7. In addition, his total bilirubin rose to 7.1 mg/dL from baseline 2.4 mg/dL. He underwent an allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA haploidentical related donor (Fig. COVID-19 with anemia is typically treated by managing COVID-19 and its symptoms. Iron and iron-related proteins in COVID-19. Another 2021 study looked at people who were readmitted to the hospital after clearing COVID-19. Hosoi H, Tane M, Kosako H, Ibe M, Takeyama M, Murata S, Mushino T, Sonoki T. J Autoimmun. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. COVID-19 treatments and medications. Addition of 40% aNHS with various concentrations of the spike protein to type O-positive erythrocytes from a patient with PNH (49% PNH red blood cell clone: 25% type III and 24% type II cells) and type O-positive erythrocytes from a healthy control, incubated at 37C for 1 hour. doi: https://doi.org/10.1182/blood.2021011548. This is a condition where you dont have enough healthy red blood cells (RBCs). Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination. Accessibility Thalassemia can cause mild or severe anemia. Lee E.J., Cines D.B., Gernsheimer T., Kessler C., Michel M., Tarantino M.D., et al. Submucosal fibroids are associated with heavy menstrual bleeding, causing an estimated 5% to 10% of cases of abnormal uterine bleeding. When inflammation is present, the bodys absorption and movement of iron is disrupted. Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients performance: A prospective observational cohort study. Last medically reviewed on March 9, 2023. SARS-CoV-2 Infection in Aplastic Anaemia. Nitahara Y, Nakagama Y, Kaku N, Candray K, Michimuko Y, Tshibangu-Kabamba E, Kaneko A, Yamamoto H, Mizobata Y, Kakeya H, Yasugi M, Kido Y. Microbiol Spectr. Autoimmune cytopenias can be trigger by vaccines and viral infections by involving molecular mimicry and circulating immune complexes, including SARS-Cov2. These events and reported side-effects could be simply temporally related rather than directly attributable to vaccination. His iron, ferritin and red blood cell count is extremely low. Rev. (2019). Dolberg O.J., Levy Y. Idiopathic aplastic anemia: diagnosis and classification. Patient 1 had a presumptive thrombotic manifestation. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. Bethesda, MD 20894, Web Policies When Although many vaccines can lead to hemolysis and thrombosis in PNH, this effect is mitigated in most patients on complement inhibitors.15 Ravulizumab, a new C5 inhibitor with a half-life 4 times longer than eculizumab, is reported to have significantly fewer instances of pharmacokinetic breakthrough hemolysis.16 Furthermore, 3 instances of breakthrough hemolysis occurred 4 weeks from the last ravulizumab infusion, making suboptimal C5 inhibition unlikely. A coordinator will follow up to see if Mayo Clinic is right for you. Going to a Cleveland Clinic location? Sonnweber T, et al. Is there a particular reason why he is donating so frequently? However, each individual may experience symptoms differently. My husband has never had any history of anemia or low iron. When your child has aplastic anemia, their bodys bone marrow isnt making enough white and red blood cells or platelets (cells that help their blood clot). The Covid-19 vaccines are very good at reducing the risk of hospitalization and death for the person who gets vaccinated. Baden LR, El Sahly HM, Essink B, et al.. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. Among patients with SARSCoV2 infection (also known as COVID19), pneumonia, respiratory failure and acute respiratory distress syndrome are frequently encountered complications. Do you have a history of anemia or another blood disorder? Three patients developed Hb levels below 7 with anemic syndrome and platelets below 50,000 but without purpuric syndrome; they received the same treatment as patients with autoimmune thrombocytopenia and reached complete remission too. Prognostic role of anemia in COVID-19 patients: A meta-analysis. 1. 8600 Rockville Pike What are the treatment options for anemia and COVID-19? Anemia was mostly mild and associated with inflammation. We report a case of severe AA that arose after the administration of a COVID-19 vaccine In this patient, antibodies against the SARS-CoV-2 spike protein were detected both before and after the HSCT. The development of various autoimmune diseases has been reported after COVID-19 infections or vaccinations. -, Harada Y, Yamamoto H, Sato M, Kodaira M, Kono T. Autoimmune hemolytic anemia during adalimumab treatment for plaque psoriasis. Histological findings of the bone marrow biopsy specimen at diagnosis. (2022). Aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome. The Centers for Disease Control and Prevention approved all three vaccines. Following his second dose, he noted fevers, diarrhea, vomiting, severe fatigue, and dark urine. ), and the Jack LevinC. Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes. HSCT, hematopoietic stem cell transplantation; N.A., not applicable; SARS-Cov-2, severe acute respiratory syndrome coronavirus 2. Tests for immunoglobulin G against cytomegalovirus and Epstein-Barr virus produced positive results, but were not indicative of virus reactivation. All patients with Evans syndrome developed hemolysis and low platelet counts. Panel A: Hematoxylin, Evaluation of neutrophil count, The X-axis indicates the number of days after the, MeSH This means that less dietary iron is absorbed from your digestive tract and that the iron already in your body doesnt move out of storage. Further evaluations in large cohorts are warranted to elucidate the associations between AA and SARS-CoV-2 vaccines. Search for other works by this author on: Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. The allogeneic BMT was conducted at 34 days after the 2nd dose of the COVID-19 vaccine was administered. This is especially important if you are older or Lee NCJ, et al. 2023 Apr;201(2):227-233. doi: 10.1111/bjh.18627. Research has found that COVID-19 with anemia is associated with more severe symptoms in people hospitalized for COVID-19. Panel A: Hematoxylin and eosin (H.E.) Go to the Blood Cancers & Disorders Support Group. Discussion of the hematologic complications of vaccination for severe acute respiratory syndrome coronavirus-2 (COVID-19) has primarily focused on the development of vaccine-associated immune thrombosis with thrombocytopenia (VITT). 2022 Sep 28;3(4):1442-1444. doi: 10.1002/jha2.570. The most common adverse effects following the vaccination are flu-like symptoms such as soreness, fatigue, myalgia, headache, chills, fever, joint pain, nausea, muscle spasm, sweating, dizziness, flushing, feelings of relief, brain fogging, anorexia, localized swelling, decreased sleep quality, itching, tingling, diarrhea, nasal stuffiness, Conflict-of-interest disclosure: R.A.B. Sometimes there are coincidences. This suggests that postvaccination hemolysis is not mediated by the direct effect of the spike protein. Characteristics of patients with PNH and COVID-19 vaccine reactions. Recent data suggest the SARS-CoV-2 spike protein binds heparan sulfate on nucleated cells9 and amplifies the alternative pathway of complement through interference with the binding of CFH, an alternative pathway inhibitor.5 However, CFH primarily binds sialic acid on human erythrocytes,10 and mature erythrocytes express little heparan sulfate.11. The administration of granulocyte-colony stimulating factor had no effect on his neutropenia. J. Autoimmun. I fed him an iron rich diet the week prior to him giving blood. Let's look at why and how to get support to stop drinking: While not as serious as other causes of chest pain, anemia-related chest pain can be a sign that your current treatment plan isn't working. Thirty-six with autoimmune thrombocytopenia, all were preexisting. "Good afternoon and welcome to Mayo Connect. Laboratory tests showed that his white blood cell count (1.6109/l) and platelet count (11109/l) were decreased. and T32 HL 007525 (G.F.G. Vaccine response will be measured 28 and 56 days after the first vaccine administration in both groups. (2021). designed and performed research; J.Y., B.A.Y.C., E.M.B., and S.C. interpreted results and edited the paper; R.A.B. Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial. However, it is possible that he had some other (possibly unrecognized) infection that caused this sometimes iron is depleted in the body while the system is fighting an infection. An official website of the United States government. Before A position paper from the SAAWP of the EBMT, Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity, Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation, Thrombotic events with Neisseria meningitidis vaccination in patients with paroxysmal nocturnal hemoglobinuria, UK experience [abstract], Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria, Complementopathies and precision medicine, 2021 by The American Society of Hematology. Insights into new-onset autoimmune diseases after COVID-19 vaccination. 1998-2023 Mayo Foundation for Medical Education and Research. Thank you for submitting a comment on this article. Panel A: Hematoxylin and eosin (H.E.) In this case, antibodies derived from the COVID-19 vaccine may not have been directly involved in the development of AA. Appendix ASupplementary data to this article can be found online at https://doi.org/10.1016/j.jaut.2021.102782. Five days after receiving the second dose of the Pfizer-BioNTech vaccine, he developed abdominal pain leading to evaluation in an emergency department. Further epidemiological evaluations of the incidence of AA after COVID-19 infection and SARS-CoV-2 vaccination are warranted. We have safe and effective vaccines that protect against COVID-19 infection. FOIA Although causality was not proven in this case, further evaluations are warranted to assess the associations between vaccines and AA. Further studies are needed to investigate the impairment of hematopoiesis induced by immune reactions after SARS-CoV-2 vaccine administration. Transfusion. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Symptoms of submucosal fibroids include: 3. To be approved, the vaccines must go through a careful trial process with several phases to address safety and effectives. Additionally on danicopan; however, 2 doses were missed immediately following vaccination. After the allogeneic HSCT, the patient's AA was ameliorated despite the presence of antibodies against SARS-CoV-2. Use VaxFinder to search for appointments. The .gov means its official. Why vaccines do not work as well in Africa remains uncertain. Everything is as it should be: Meet @dsh33782. Aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome. Anemia of inflammation can also happen with a variety of other conditions associated with inflammation in the body, including autoimmune diseases and cancer. Autoimmun. Rehabilitation Committee of Hematological Diseases, Chinese Association of Rehabilitation Medicine;; Chinese Society of Hematology, Chinese Medical Association. Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination. Erythrocyte lysis with addition of the SARS-CoV-2 spike protein S1. Correspondence: Robert A. Brodsky, Division of Hematology, School of Medicine, Johns Hopkins University, 720 Rutland Ave, Ross Research Bldg, Room 1025, Baltimore, MD 21205; e-mail: brodsro@jhmi.edu. As a result, theres less iron available for hemoglobin on new RBCs. Gadi SRV, Brunker PAR, Al-Samkari H, Sykes DB, Saff RR, Lo J, Bendapudi P, Leaf DE, Leaf RK. Epub 2021 Nov 10. Good morning! In conclusion, the administered SARS-CoV-2 mRNA vaccine may have contributed to the pathogenesis of AA in this case. Conversely, there is quite a bit of information on the importance of not going into the vaccine with iron deficiency due to the way in which the vaccine works. GUID:8CF21491-3982-4BE9-BC13-2CC39963ADC6, COVID-19, SARS-CoV-2, Vaccination, Aplastic anemia, Bone marrow transplantation. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Donnini I., Scappini B., Guidi S., Longo G., Bosi A. UConn previously required all students to be COVID-19 vaccinated starting in 2021 during a surge of the pandemic to maintain the health and safety of the UConn community. There is no established method for examining the relationships between vaccines and the development of autoimmune diseases. Talk with your doctor and family members or friends about deciding to join a study. Hemolytic anemia in COVID-19. He received the", "My husband gives blood regularly. However, it is not clear whether antibodies derived from the SARS-CoV-2 vaccine directly contributed to the development of AA because the anti-SARS-CoV-2 antibodies remained after the patient's pancytopenia had been ameliorated by the allogeneic HSCT. 2022 Nov 4;4(1):288-90. doi: 10.1002/jha2.602. Good afternoon and welcome to Mayo Connect. Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance. Unauthorized use of these marks is strictly prohibited. Thalassemia can cause mild or severe anemia. Three patients developed counts below 30,000 with purpuric symptoms and needed treatment that consisted in two courses of dexamethasone 40 mg daily for four days every three weeks; all patients reached complete remission without any further treatment. The FDA has approved the Moderna vaccine, now The relationship between the messenger ribonucleic acid vaccine and hemolytic PMC He received the Pfizer vaccine in March. Studies have confirmed the safety and efficacy of the available SARS-CoV-2 vaccines. 2021 May 15;13(5):e15035. A growing number of studies now suggest that people with this painful genetic blood disorder who also are infected with SARS-CoV-2, the virus that causes COVID-19 disease, are more vulnerable to severe health complications than the rest of the population. Bethesda, MD 20894, Web Policies To test the effect of the SARS-CoV-2 spike protein on hemolysis, we performed erythrocyte lysis using erythrocytes from a patient with PNH and acidified normal human serum (aNHS) with addition of the SARS-CoV-2 spike protein subunit 1 (S1) (see supplemental methods, available on the Blood Web site). Because the function of RBCs is to deliver oxygen, having anemia means that the organs and tissues of your body arent getting enough oxygen. One of the most feared adverse reactions to vaccines is the development of autoimmune disease. With respect to its etiology, it can be idiopathic Other types of anemia have also been reported in people with COVID-19, but these are much less common. Plus, inflammation in the body can reduce the production of new RBCs in the bone marrow. The titers of antibodies against SARS-CoV-2 before the conditioning regimen and 63 days after the HSCT were 540 and 34.9 U/mL (reference range, <0.8 U/mL), respectively (Fig. Briefly, type O-positive red blood cells from 1 patient with PNH and 1 control were collected. Careers, Unable to load your collection due to an error. The https:// ensures that you are connecting to the mRNA-1345 is a single messenger RNA (mRNA) sequence encoding for a stabilized prefusion F glycoprotein, using the same lipid nanoparticles as the companys It may take up to 24-30 weeks for your body to replace the iron lost through a blood donation. 2021;384(5):403-416. Notably, she took danicopan throughout her first vaccination and did not experience breakthrough hemolysis. Please enable it to take advantage of the complete set of features! receives research funding from Alexion. If you have anemia with COVID-19, it could affect your recovery. He saw his physician and she suspected some type of internal bleeding based on the blood test, He had an upper and lower endoscopy. 2021 Nov;61(11):3267-3271. doi: 10.1111/trf.16672. My husband has never had any history of anemia or low iron. The patient was diagnosed with very severe AA [6]. J. Med. Hemolysis is not increased with addition of the SARS-CoV-2 spike protein S1 to PNH erythrocytes. Introduction. Avenoso D., Marsh J.C.W., Potter V., Pagliuca A., Slade S., Dignan F., et al. This site needs JavaScript to work properly. The efficacies of the Covid-19 vaccines have not been as high as initially reported. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). To treat the low blood counts, early treatment involves easing symptoms. Lenehan PJ, et al. The gray boxes indicate the titers of antibodies against the SARS-CoV-2 spike protein (log scale). See additional information. It is important to notice that patients with hemolytic autoimmune anemia secondary COVID-19 had severe relapse, event that support the mimicry mentioned lines above. Based on hearing this question a second time, I dove into everything I could find about vaccines and iron deficiency there just is no data, anywhere to suggest a link. They can include: Anemia can happen with COVID-19, typically due to increased levels of inflammation in the body. Hsu CM, Weiner DE, Manley HJ, Aweh GN, Ladik V, Frament J, Miskulin D, Argyropoulos C, Abreo K, Chin A, Gladish R, Salman L, Johnson D, Lacson EK Jr. Clin J Am Soc Nephrol. We postulate that strong complement amplification as a byproduct of the inflammatory response is responsible for the clinically observed hemolysis, as has been reported with other vaccines, infections, and surgeries. Aplastic anemia following the severe acute respiratory syndrome coronavirus-2 vaccine. He had no history of COVID-19 infection. Unable to load your collection due to an error, Unable to load your delegates due to an error. Yes. We report a case in which AA developed after the administration of a SARS-CoV-2 vaccine. Inclusion in an NLM database does not imply endorsement of, or agreement with, In this patient, antibodies against the SARS-CoV-2 spike protein were detected both before and after the HSCT. His symptoms resolved after 5 days. Hemolysis in each sample was compared with total water-induced lysis of the erythrocytes. 2021;62(10):1510-1514. doi: 10.11406/rinketsu.62.1510. All COVID-19 vaccines available in the U.S. are safe for people with sickle cell disease. All rights reserved. There are no funding sources associated with the writing of this manuscript. Why Should I Register and Submit Results? However, rare cases of adverse immunological reactions to SARS-CoV-2 vaccines have been reported, including cases involving immune-mediated disease [[1], [2], [3]]. Tao Z, et al. Here, we report a case of AA that developed after the administration of a SARS-CoV-2 vaccine and discuss the association between AA and vaccination. Please check for further notifications by email. Twenty-three patients with autoimmune thrombocytopenia did not develop any fall in the platelet count.