This lowers the level of eosinophils in your body, relieving symptoms of eosinophilic asthma. When administered subcutaneously to patients with asthma, Fasenra has a bioavailability of 59%. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps. The following lists contain some of the key side effects that may occur while taking Fasenra. Before leaving the office or clinic, make sure that you have an appointment for your next Fasenra injection scheduled. Some people may have an allergic reaction to Fasenra. In comparison, 6% of people who took a placebo had headaches. Wash your hands and clean the injection site with an alcohol swab. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. Fasenra will not treat an asthma attack or exacerbations of asthma (acute bronchospasm or status asthmaticus). Uncontrolled asthma is when a person has frequent and disruptive asthma symptoms, such as wheezing, chest tightness, or asthma attacks. Youll use Fasenra with your other asthma medications rather than by itself. Asthma is called severe when you keep having symptoms despite using multiple asthma treatments. How a drug works is referred to as its mechanism of action., Fasenra is used to treat severe eosinophilic asthma in adults and some children. Get medical help right away, if you have any of the symptoms listed above. People can be taught how to self-administer Fasenra. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. It also helps reduce blood eosinophils, which are a type of white blood cell that may contribute to your asthma. What happens when you stop taking Fasenra? The dose of this medicine will be different for different patients. But if your throat pain is severe or lasts more than a few days, tell your doctor. Applies to benralizumab: subcutaneous solution. Its not known for sure if Fasenra is safe to use while youre breastfeeding. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. However, elderly patients are more sensitive to the effects of this medicine than younger adults. No generic of Fasenra is currently available. If needed, your doctor can recommend treatments to help you feel better. Heres some information about the uses of Fasenra and Dupixent. Fasenra can be kept at room temperature for up to 14 days if necessary. Seek medical advice if your asthma worsens while on Fasenra. Fasenra belongs to the class of medicines known as interleukin inhibitors. To administer the Fasenra autoinjector pen, first, remove the clear needle cap from the end of the autoinjector by pulling it off. But it should be discarded if not used within this time and should not be put back into the refrigerator. If youre not sure if youll need to get prior authorization for Fasenra, contact your insurance company. And if your asthma symptoms ever feel life threatening, call 911 or seek emergency medical help. Fasenra is used to treat severe eosinophilic asthma in adults and in children ages 12 years and older. They can also discuss with you the best treatment for your condition. If you use a corticosteroid medicine (inhaled or taken by mouth) to control your asthma, keep using it unless your doctor tells you otherwise. The number of people who develop asthma and allergies grows yearly. Fasenra (benralizumab)." For details, see the How is Fasenra used? section below. (An active drug is an ingredient that makes a medication work.) The Food and Drug Administration (FDA) approves prescription drugs such as Fasenra to treat certain conditions. This can help avoid any potential drug interactions. Fasenra currently isnt approved by the Food and Drug Administration (FDA) for treating nasal polyps. If you receive Fasenra while pregnant, consider joining the Fasenra pregnancy registry. Theyre both given as an injection under the skin. They can review the benefits and possible risks of breastfeeding while using this drug. If you use this medicine at home, you will be shown the body areas where this shot can be given. Pregnancy registries gather data on the safety of using medications such as Fasenra during pregnancy. * Xolair has a boxed warning for a severe allergic reaction called anaphylaxis. If you have a sore throat while using Fasenra, itll probably improve on its own within a few days. Fasenra is currently approved as an add-on . Eosinophil cationic protein (ECP) levels are also significantly reduced after treatment with Fasenra. Fasenra should not be shaken, frozen, or exposed to heat. chronic obstructive pulmonary disease (COPD). But another similar study is still gathering data about whether Fasenra might be an effective treatment for COPD. Fasenra is prescribed using a standard dosage. If youre pregnant or breastfeeding, or planning to become pregnant or breastfeed, talk with your doctor about the benefits and risks of Fasenra treatment during this time. Asthma and Allergies on the Rise in the U.S. Keep this container away from children and pets. Fasenra is a monoclonal antibody (IgG1, kappa) that binds to IL-5R, the alpha subunit of the human interleukin-5 receptor. A significant improvement in lung function was also observed 4 weeks after Fasenra was administered. Drug information provided by: Merative, Micromedex. Both forms of the drug have one strength: 30 mg/mL. This medicine may cause serious allergic reactions, including anaphylaxis and angioedema. Each vial, autoinjector pen, or syringe contains one dose of Nucala. These cells cause inflammation (swelling) and trigger asthma flare-ups. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Before taking Fasenra, talk with your doctor or pharmacist. Below are examples of these side effects. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of benralizumab injection in the elderly. After an initial loading dose where Fasenra is injected once every 4 weeks for the first 3 doses, it only needs to be given once every 8 weeks. But if you dont use the Fasenra pens within that time frame, you must dispose of them. Research has shown approximately 12% of people receiving Fasenra develop antibodies to it, which has been associated with increased clearance of Fasenra and increased blood eosinophil levels. All the people in the studies were also taking at least two other medications to treat their asthma. You may have questions about Fasenra and your treatment plan. There are currently no biosimilar forms of either drug available. The risks vs benefits need to be weighed up. Such studies help doctors learn more about the safety of certain drugs during pregnancy. They can let you know whether its safe for you to take Fasenra and recommend other treatment options if needed. It is unknown what effect Fasenra has on an unborn baby. (A drug class is a group of medications that work in a similar way in your body.). The pain this condition causes can be debilitating, causing severe pain in the lower back and buttocks. Dupixent (dupilumab) is a brand-name prescription medication. Benralizumab helps prevent severe asthma attacks (exacerbations) and may improve your breathing. Keep joints healthy from the get-go. Fasenra also shouldnt be used to treat other eosinophilic conditions. Fasenra (benralizumab) is an injectable drug prescribed for adults and children 12 and over who have eosinophilic asthma a rare form of asthma in which levels of white blood cells called eosinophils are abnormally high. It also helps keep the drug from harming the environment. This medicine comes in two forms: a prefilled syringe (to be given by the doctor or other healthcare professional) and prefilled autoinjector or Fasenra Pen (to be used by the patient or caregiver). Symptoms of an allergic reaction to Fasenra can include: Call your doctor right away if you have a severe allergic reaction to Fasenra. Astra-Zeneca Pharmaceuticals (2017): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Nasal polyps are growths in the lining of your nose that arent cancerous. The lists below describe some of the more common side effects that Fasenra may cause. Fasenra is a liquid solution given as an injection under the skin. Initially, your doctor will administer it, but during your appointment, they will discuss teaching you how to administer the Fasenra autoinjector pen so that you can administer it at home. These lists contain examples of serious side effects that can occur with Fasenra, with Nucala, or with both drugs (when taken individually). The goal of HES treatment . Weight gain is not reported as a side effect of Fasenra in the product information. Symptoms of a severe allergic reaction can include swelling under your skin, usually in your eyelids, lips, hands, or feet. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. To learn about other mild side effects, talk with your doctor or pharmacist, or read Fasenras prescribing information. Do not freeze Fasenra pens or expose them to heat. Fasenra isnt approved for use in children younger than age 12 years. The side effects seen in children were very similar to those seen in adults. Below are some common questions about taking Fasenra. Safety and efficacy have not been established. See additional information. These factors include what your insurance plan covers and which pharmacy you use. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Fasenra works by attaching to certain white blood cells called eosinophils. Be sure that you understand exactly how to use this. Like Nucala (above), the drug Xolair has uses similar to those of Fasenra. What is Fasenra used for and how does it work? https://www.mayoclinic.org/drugs-supplements/benralizumab-subcutaneous-route/side-effects/drg-20406682, Advertising and sponsorship opportunities. These are a type of white blood cell that are found mostly in your airways. After that, youll have one injection once every 8 weeks. Fasenra may increase your risk of herpes infection. Our website services, content, and products are for informational purposes only. Theyll recommend whether the drug is a good option for you. Im giving myself Fasenra doses at home. The systemic clearance of Fasenra is 0.29 L/day in people weighing 154 pounds (which is about 70 kilograms). Both Fasenra and Xolair are called biologic drugs because theyre made from living cells rather than from chemicals. Do not use this medicine if it is cloudy or if there are particles in it. A biosimilar is a drug thats similar to a brand-name medication. Joint pain may begin within a few days after starting Fasenra treatment or as late as one year after beginning treatment. If you have a fever after taking Fasenra, you can try to make yourself more comfortable by taking a cool bath. A generic drug, on the other hand, is an exact copy of a brand-name medication. Do not use the pen if it looks damaged or broken. No, you shouldnt. They can tell you about other medications that may work well for you. This type of drug is a large protein that affects the way certain parts of your body work. Two clinical studies found that Fasenra was not effective at preventing flare-ups in people with moderate to very severe COPD. Pain, scratchiness, or irritation in the throat may occur with Fasenra. With severe eosinophilic asthma, you have high levels of eosinophils in your body. Available for Android and iOS devices. Keep in mind that Fasenra isnt a rescue inhaler. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Symptoms of a mild allergic reaction can include: skin rash. In comparison, 2% of people who took a placebo had a fever. They also express IL-5R like eosinophils do and play a role in the airway inflammation associated with asthma. Both are given as an injection under the skin. If you are a caregiver administering Fasenra to another person, it may also be administered into the upper arm. The goal of HES treatment . Given via subcutaneous injection (under the skin). This makes it easier for you to breathe. Do not warm it in any other way. Half of the people in these studies took Fasenra and half took a placebo (treatment with no active drug). We comply with the HONcode standard for trustworthy health information. These lists contain examples of serious side effects that can occur with Xolair, or with Fasenra and Xolair (when taken individually). The usual dosage for severe eosinophilic asthma is 30mg every 8 weeks for adults and children aged at least 12 years. Fasenra is a brand-name prescription medication. By binding to IL-5, Fasenra reduces the production and survival of eosinophils.
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